dimanche 8 mai 2011

Moroccan DNA

Moroccan DNA

Recent studies make clear no significant genetic differences exist between Arabic and non-Arabic speaking populations, HLA DNA data suggest that most Moroccans are of a Berber (Imazighen) origin and that Arabs who invaded North Africa and Spain in the 7th century A.D. did not substantially contribute to the gene pool. However, they imposed their advanced culture and their religion [1] .[48] The Moorish refugees from Spain settled in the coast-towns.[49] According to the European Journal of Human Genetics, Moroccans from North-Western Africa were genetically closer to Iberians than to Sub-Saharan Africans of Bantu ethnicity and Middle Easterns.[50]
The different loci studied revealed close similarity between the Berbers and other north African groups, mainly with Moroccan Arabic-speakers, which is in accord with the hypothesis that the current Moroccan population has a strong Berber background.[2]
the E1b1b1 clade is presently found in various forms in Morocco. Total E1b1b1 (E-M35) frequencies reached at 93.8% in Moroccans [3]
E1b1b1b1(E-M81), formerly E1b1b1b, E3b1b, and E3b2, is the most common Y chromosome haplogroup in Morocco, dominated by its sub-clade E-M183. This haplogroup reaches a mean frequency of 85% to 50% In North Africa, decreasing in frequency from approximately 85% or more in Moroccan Berber populations, including Saharawis, to approximately 10% to the east of this range in Egypt. and Because of its prevalence among these groups and also others such as Mozabite, Middle Atlas, Kabyle and other Berber groups, it is sometimes referred to as a genetic "Berber marker". average North African Moroccan Berbers have frequencies of E3b3 in the +80%. Alvarez et al.(2009) study shows a frequency of E3b1b of 28/33 or 84.8% in Berbers from Marrakesh. With the rest of the frequencies being 1/33=3% E3a*, 1/33=3% E3b*, 1/33 or 3% E3b1a, and 1/33 or 3% E3b1c.[4]
The most basal and rare E-M78* paragroup has been found at Lower frequencies in Moroccan Arabs. his sub-clade: E1b1b1a1d (E-V65), is found in high levels in the Maghreb regions of far northern Africa. Cruciani et al. (2007) report levels of about 20% amongst Libyan Arab lineages, and about 30% amongst Morrocan Arabs. It appears to be less common amongst Berbers, but still present in levels of >10%. The authors suggest a North African origin for this lineage. In Europe, only a few individuals were found in Italy and Greece. Capelli et al. (2009) studied the beta cluster in Europe. They found small amounts in Southern Italy, but also traces in Cantabria, Portugal and Galicia, with Cantabria having the highest level in Europe in their study, at 3.1% (5 out of 161 people).
Other frequencies of E1b1b1a1c (E-V22) is reported by Cruciani et al. (2007) include Moroccan Arabs (7.27%, 55 people) and Moroccan Jews (8%, 50 people).

[edit] Genetic influence of North West Africans on Southern Europe

A study from Semino (published 2004) showed that Y-chromosome haplotype E1b1b1b (E-M81), is specific to North African populations and almost absent in Europe except the Iberia (Spain and Portugal) and Sicily. Another 2004 study showed that E1b1b1b is found present, albeit at low levels throughout Southern Europe (ranging from 1.5 percent in Northern Italians, 2.2 percent in Central Italians, 1.6 percent in southern Spaniards, 3.5 percent in the French, 4 percent in the Northern Portuguese, 12.2 percent in the southern Portuguese and 41.2 percent in the genetic isolate of the Pasiegos from Cantabria).[51] The findings of this latter study contradict a more thorough analysis Y-chromosome analysis of the Iberian peninsula according to which haplogroup E1b1b1b surpasses frequencies of 10 percent in Southern Spain. The study points only to a very limited influence from northern Africa and the Middle East both in historic and prehistoric times.[52] The absence of microsatellite variation suggests a very recent arrival from North Africa consistent with historical exchanges across the Mediterranean during the period of Islamic expansion, namely of Berber populations. A study restricted to Portugal, concerning Y-chromosome lineages, revealed that "The mtDNA and Y data indicate that the Berber presence in that region dates prior to the Moorish expansion in 711 AD. ... Our data indicate that male Berbers, unlike sub-Saharan immigrants, constituted a long-lasting and continuous community in the country".[53]
Haplotype V(p49/TaqI), a characteristic North African haplotype, may be also found in the Iberian peninsula, and a decreasing North-South cline of frequency clearly establishes a gene flow from North Africa towards Iberia which is also consistent with Moorish presence in the peninsula.[54] This North-South cline of frequency of halpotype V is to be observed throughout the Mediterranean region, ranging from frequencies of close to 30 percent in southern Portugal to around 10 percent in southern France. Similarly, the highest frequency in Italy is to be found in the southern island of Sicily (28 percent).[55][56]
A wide-ranging study (published 2007) using 6,501 unrelated Y-chromosome samples from 81 populations found that: "Considering both these E-M78 sub-haplogroups (E-V12, E-V22, E-V65) and the E-M81 haplogroup, the contribution of northern African lineages to the entire male gene pool of Iberia (barring Pasiegos), continental Italy and Sicily can be estimated as 5.6 percent, 3.6 percent and 6.6 percent, respectively."[56]
A very recent study about Sicily by Gaetano et al. 2008 found that "The Hg E3b1b-M81, widely diffused in northwestern African populations, is estimated to contribute to the Sicilian gene pool at a rate of 6 percent." .[57]
According to the most recent and thorough study about Iberia by Adams et al. 2008 that analysed 1,140 unrelated Y-chromosome samples in Iberia, a much more important contribution of northern African lineages to the entire male gene pool of Iberia was found : "mean North African admixture is 10.6 percent, with wide geographical variation, ranging from zero in Gascony to 21.7 percent in Northwest Castile".[58][59]

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